1/9/2024 0 Comments Gram negative![]() In this paper, I explain the immune response's phagocytic mechanisms that occurs prior to the development of sepsis and identify the features of phagocytosis that may act as a predictive marker for the outcome of the disease. Only a few research studies, however, have particularly investigated and defined the effects of immunosuppression on phagocytic activity during sepsis as a result of the infection. As a result, phagocytosis plays an important function in sepsis and presumably contributes to most clinical phases of the disease. Specifically, it has been demonstrated that hydroxyl radicals play a role.Īn extensive network of complicated phagocytic mechanisms is implicated in the development of sepsis. It has been demonstrated that free radicals such as nitric oxide (NO), peroxynitrite (ONOO-), and hydrogen peroxide are involved in these effects. Sepsis pathophysiology includes infection by gram negative or positive bacteria, an elevated inflammatory reaction lower blood pressure that may result in vasodilatory shock and reduction of oxygen delivery to organs as a response to cell dysfunction. ![]() Oxidative stress is defined by elevated intracellular levels of reactive oxygen species (ROS) that cause damage to lipids, proteins, and DNA. As a result of a pathogen triggering the Systemic Inflammatory Syndrome (SIRS), sepsis is an immunological condition that is diagnosed based on patterns of temperature, heart rate, respiration, and white blood cell (WBC) count.Īlthough the pathogenesis of sepsis remains unclear, there is growing evidence that oxidants and antioxidants play a major role. People respond differently to infection, which is evidence that individuals have varying degrees of immune suppression. Even with adequate treatment, severe sepsis affects over 49 million people worldwide and is responsible for approximately 11 million deaths each year. Globally, sepsis is one of the largest causes of death in acute care units.
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